Endocrinopathy due to an overactivity of eosinophilic cells of the anterior hypophyseal lobe (adenoma/hyperplasia) with an increased growth-hormone (somatotropin) production. After the epiphyseal plates are closed, this results in enlargement of acral parts (hands, feet, chin, and nose).
- Joint pain
- Enlarged nose and lips
- Enlarged tongue and ears
- Excessive mandibular growth causing prognathism
- Prominence of zygomatic bones and maxillary sinus enlargement
- Disturbed vision due pressure from the hypophysis on the optic chiasm
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